T cells are immune cells, activated as an adaptive immune response to release cytokines that help innate and adaptive immunity. These cells do not bind to pathogen but bind to peptides generated by the degradation of these pathogens and presented on major histocompatibility (MHC) complex molecules, found in antigen presenting cells such as dendritic cells, B-cells, and macrophages. These T cells have receptors with alpha (light): beta (heavy) chain or in some rare cases, they have gamma: delta chain. These chains are synthesized in the thymus and are derived from the same precursor (Parham 79). There are two classes of MHC molecules, MHCI and II. The naÃ¯ve T cells in the secondary lymphoid; when they encounter an antigen presented on MHC of dendritic cells, they differentiate and proliferate into effector T cells, CD8 or CD4 T cells depending on the class of MHC antigen complex the naÃ¯ve T cell bind to. These effector T cells then are transported to the site of infection where they encounter target cells with specific antigen MHC complex. The target cells activate these effector CD8 (binds to MHCI) and CD4 (binds to MHCII antigen complex) into cytotoxic T cells and helper T cell 1 Th1.
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