ARAâ€™s Effect on Human Health
Much interest has been shown toward ARA’s manufacturing because of its significance to human health. A significant effect of ARA has been observed in the brain and building up of the body mass.
ARA is present in the brain in similar quantities as docosahexaenoic acid (DHA). Together they make up about 20% of the total fatty acid content. Therefore, a combination of ARA and DHA is used for better results.
ARA is known to prevent neurons from oxidative stress caused by peroxisome proliferators. Activated gamma receptors prevent oxidation. ARA also helps maintain neurological health and fluidity of the membrane of the hippocampus.
If the metabolism of ARA is disturbed, neuropsychiatric disorders such as Alzheimerâ€™s may be observed.
ARA is sold commercially as a supplement for bodybuilding. It assists in increasing body mass and strength and anaerobic power in men undergoing rigorous resistance training.
ARA contributes to inflammation when the cells suffer any injury.
ARA is involved in cell signaling and regulates the signaling enzymes.
It also acts as a lipid messenger.
ARA helps in the growth and repair of skeletal muscles. The skeletal muscle tissues are converted to prostaglandin F2alpha (PGF2Î±), which occurs during or after physical exercise.
Commercial Production of Arachidonic Acid
Polyunsaturated fatty acids play a crucial role in human health. However, their production on a commercial level is difficult, and demand precedes its supply. ARA is a nutraceutical lipid commercially produced from the fungus Mortierella alpina (M. alpina) strains ME-1 and 1S-4 are used to produce ARA on an industrial scale. These two strains have a high oleaginous capacity, regulate lipogenesis, and produce poly-unsaturated fatty acids (PUFA). The strains absorb and transform exogenous fatty acids. Approximately 30% to 70% of fatty acids can be produced from the fungus with 50% biomass. Fermentation of such lipid-rich fungal biomass produces ARA industrially. ARA-rich oil is extracted and purified after the fermentation process. There are two types of fermentation; submerged fermentation and solid-state fermentation. Between the two kinds of fermentation, submerged fermentation is more favored. In submerged fermentation, it is comparatively easier to increase the level of biomass recovery and the yield of the ARA produced. Moreover, less fermentation time is needed. A total of 410 tons of ARA are expected to be produced by 2025, but scientists have confirmed that this would not be enough to meet the demand.
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